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Gastroesophageal reflux disease (GERD) is notable for its high prevalence, variety of clinical presentations, under-recognized morbidity, and substantial economic consequences. This topic will review the clinical manifestations and diagnosis of GERD. The pathophysiology and management of GERD are discussed in detail separately.

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UpToDate is a trusted source of clinical information for health professionals. However, the page you are looking for can't be found. Try searching for a different topic or language.In some cases, heart failure can be mild and cause minor symptoms that are only evident with physical activity. Other times it can be severe (causing symptoms at rest) or even life-threatening. The most common symptoms of heart failure are shortness of breath, fatigue, leg swelling, and other signs of fluid retention. UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improve patient care. Nov 10, 2023 · Pneumococcal vaccination is indicated for adults with risk factors for pneumococcal disease or for severe adverse outcomes should disease occur. Pneumococcal vaccination is also a routine part of infant and childhood immunization schedules worldwide. This topic will review types of pneumococcal vaccines, indications and approach to vaccine ... The global prevalence of hypertension is high, and among nonpregnant adults in the United States, treatment of hypertension is the most common reason for office visits and for the use of chronic prescription medications [ 1-3 ]. In addition, roughly one-half of hypertensive individuals do not have adequate blood pressure control.

- Typical lab characteristics of DKA and HHS - Precipitating factors DKA and HHS - DKA rapid overview (adults) - ADA DKA HHS water deficit - Laboratory evaluation of metabolic acidosis and coma - Major causes of metabolic acidosis CALCULATORS. Calculator: Plasma sodium concentration correction for hyperglycemia in adults …Intrauterine tamponade (with a balloon, packing, or vacuum) may be used to manage patients with postpartum hemorrhage (PPH) resulting from uterine atony that is not controlled by uterotonic medications and uterine massage. However, outcome data regarding vacuum-induced tamponade are limited.Licensed to: UpToDate Marketing Professional Support Tag : [0502 - 104.224.13.121 - 80CD775346 - PR14 - UPT - 20240504-17:39:40UTC] - SM - MD - LG - XL Loading

With so much change in the world of patient care, it is clear that access to continuously updated and reliable data is critical for both provider and patient satisfaction. …

INTRODUCTION. Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy (TMA) caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13. It is characterized by small-vessel platelet-rich thrombi that cause thrombocytopenia, microangiopathic hemolytic anemia, and …Display complete list of interactions for an individual item by clicking item name. Add another item to analyze for potential interactions. NOTE: This tool does not address chemical compatibility related to I.V. drug preparation or administration. View interaction detail by clicking on link (s) below.The preventive treatment of episodic migraine headache in adults is reviewed here. The clinical features and management of chronic migraine (defined as ≥15 headache days per month) are discussed separately. (See "Chronic migraine" .) Other aspects of migraine are reviewed elsewhere.- Advantages and disadvantages of oral anticoagulants - LMW heparin dosing renal insufficiency (adults) - Anticoagulant dose adjustment in liver disease - Possible contraindications to anticoagulation - Standard dosing of DOACs - DOACs PK and drug interactions - Inhibitors and inducers of P-glycoprotein drug efflux - DOAC absorption …Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.

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Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.UpToDate® and the American Heart Association are collaborating to present select content abstracts on “What’s New in Cardiovascular Medicine.” UpToDate is an evidence-based, clinic...Feb 27, 2024 · The clinical approach to S. aureus bacteremia consists of careful history and physical examination, infectious disease consultation, and diagnostic evaluation including echocardiography and additional imaging as needed. History and physical examination. History – A careful history and physical examination is essential. Group A Streptococcus (GAS), or Streptococcus pyogenes, is the leading bacterial cause of tonsillopharyngitis in adults and children worldwide. GAS is one of the few causes of tonsillopharyngitis or pharyngitis for which antibiotic treatment is recommended. The treatment and prevention of group A streptococcal tonsillopharyngitis is reviewed here.Dec 11, 2023 · Patient level information — UpToDate offers two types of patient education materials. The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials.

Mar 28, 2024 · Choice of initial therapy in most patients — The three primary options for antihypertensive drug therapy in most patients include an ACE inhibitor (or ARB), a calcium channel blocker, or a thiazide diuretic (preferably a thiazide-like diuretic) [ 3 ]. A table summarizing the emergency management of acute hyponatremia in adults is provided ( table 1 ). An alternative approach, recommended in by European organizations, is to treat with two 150 mL bolus infusions of 3 percent saline, each given over 20 minutes, measuring the serum sodium between infusions [ 28 ].INTRODUCTION. The management of infective endocarditis (IE) includes prompt diagnosis, treatment with antimicrobial therapy, and in some cases of complicated IE, surgical management. Preventive measures including antimicrobial prophylaxis may reduce the risk of initial and recurrent IE for patients with relevant risk factors.Symptoms and signs — Rhabdomyolysis is characterized clinically by the triad of myalgias, muscle weakness, and red to brown urine due to myoglobinuria [ 1 ]. Biochemically, several serum muscle enzymes are elevated, including CK. The degree of muscle pain and other symptoms varies widely. Most of the symptoms of rhabdomyolysis are nonspecific.Estrogen is an appropriate treatment for prevention of osteoporosis in young women whose ovaries do not make estrogen. This treatment may be given as a skin patch or orally, such as in the form of birth control pills. (See "Patient education: Absent or irregular periods (Beyond the Basics)" .)The clinical features of KD reflect widespread inflammation of primarily medium-sized muscular arteries. Diagnosis is based upon evidence of systemic inflammation (eg, fever) in association with signs of mucocutaneous inflammation. The characteristic bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, …Clearview AI has been hit with another fine in France over non-cooperation with the data protection regulator. Clearview AI, the U.S. startup that’s attracted notoriety in recent y...

EVALUATION AND DIAGNOSIS. The history and physical examination in patients presenting with a severely elevated blood pressure (or an acute rise in blood pressure over a previously normal baseline, even if the presenting pressure is <180/120 mmHg) should determine whether any of the following are present [ 1,5 ]: Acute head …

Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.Cellulitis is an infection of the skin and underlying soft tissue. The infection is usually caused by bacteria, such as staphylococci ("Staph") or streptococci ("Strep"); these commonly live on the skin or inner surface of the nose or mouth among healthy people. For many people, these skin bacteria never cause infection. UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improve patient care. Cellulitis is an infection of the skin and underlying soft tissue. The infection is usually caused by bacteria, such as staphylococci ("Staph") or streptococci ("Strep"); these commonly live on the skin or inner surface of the nose or mouth among healthy people. For many people, these skin bacteria never cause infection.Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or …General symptoms — Thyroid hormone normally stimulates the metabolism, and most of the symptoms of hypothyroidism reflect slowing of metabolic processes. General symptoms may include fatigue, sluggishness, slight weight gain, and intolerance of cold temperatures. Skin — Hypothyroidism can decrease sweating.The pericardium is a fibroelastic sac made up of visceral and parietal layers separated by a (potential) space, the pericardial cavity. In healthy individuals, the pericardial cavity contains 15 to 50 mL of an ultrafiltrate of plasma. Diseases of the pericardium present clinically in one of several ways: Acute and recurrent pericarditis.Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.Management of insomnia requires a stepwise approach, beginning with attempts to eliminate, or at least minimize, the multiple contributing factors and comorbid illnesses that can interfere with optimal sleep. Insomnia often responds only partially to treatment of sleep-impairing influences, however, and many patients require treatment …

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- Diagnostic criteria for chronic insomnia disorder (ICSD-3-TR) - Nonbenzodiazepine BZRAs in the management of insomnia in adults - Other drugs for the management of insomnia in adults - Safe medication prescribing practices for insomnia - US scheds controlled drugs - Benzodiazepines in the management of insomnia in adults - …

Measures to cut down on leveraged crypto trades could entice institutional buyers and make bitcoin more useful as a currency. In an effort to curb cryptocurrency speculation, finan...About UpToDate UpToDate is the evidence-based, point-of-care resource trusted for reliable clinical answers around the world. UpToDate incorporates the latest medical findings, the best available evidence, and practical recommendations for patient care — so whatever your clinical question, you can be sure to find the answers you need.For individuals with skin abscess, we suggest initial treatment with parenteral antibiotics in the following circumstances: Systemic signs of toxicity (eg, fever >100.5°F/38°C, hypotension, sustained tachycardia) Rapid progression of erythema or abscess. Extensive abscess or surrounding erythema.Clostridioides difficile infection (CDI) is one of the most common hospital-acquired (nosocomial) infections and is an increasingly frequent cause of morbidity and mortality among older adult hospitalized patients [ 1-3 ]. CDI is also increasingly diagnosed in younger patients and in the community.Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.However, daytime use of CR tablets may exacerbate motor fluctuations and can lead to delayed-onset dyskinesia. Carbidopa-levodopa extended-release (ER) capsules show promise in reducing motor complications, but more widespread use is limited by cost and difficulties of converting from levodopa tablets to ER capsules.Potassium enters the body via oral intake or intravenous infusion, is largely stored in the cells, and is then excreted in the urine. The major causes of hyperkalemia are increased potassium release from the cells and, most often, reduced urinary potassium excretion ( table 1 ). This topic will review the causes and evaluation of hyperkalemia.Oct 6, 2023 · PARENTERAL DRUGS. A variety of parenteral and oral antihypertensive drugs are available for use in these patients ( table 1) [ 1-7 ]. Few studies have compared these agents with one another, and all are tolerated reasonably well [ 8,9 ]. Thus, the drug of choice is often dictated by the type of hypertensive emergency and the local hospital ...

Use the resource trusted by healthcare practitioners worldwide. Patients and their caregivers can learn more about a medical condition and explore treatment options using UpToDate, the same resource trusted by more than 2 million clinicians around the world. After you read the information in UpToDate, you will have the tools and the confidence ... Sep 7, 2022 · Chronic diarrhea is defined as three or more loose stools daily for at least four weeks. There are many possible causes of chronic diarrhea. Treatment is aimed at treating the underlying cause of diarrhea (whenever possible), firming up loose stools, and dealing with any complications of diarrhea. May 6, 2022 · The signs and symptoms of anemia include paleness, weakness, and fatigue. Impaired kidney function — The excess proteins and high blood calcium levels associated with MM can damage the kidneys. Kidney function is abnormal at diagnosis in about half of individuals with multiple myeloma. Beta-lactamases are enzymes that open the beta-lactam ring, inactivating the antibiotic. The first plasmid-mediated beta-lactamase in gram-negative bacteria was discovered in Greece in the 1960s. It was named TEM after the patient from whom it was isolated (Temoniera) [ 2 ]. Subsequently, a closely related enzyme was discovered and named TEM-2.Instagram:https://instagram. mcdo free Hypoglycemia is the most common acute complication of glucose-lowering therapy and is associated with poor outcomes and quality of life in people with type 1 and type 2 diabetes. Hypoglycemia is more common among patients with type 1 diabetes than those with type 2 diabetes and is usually limited to patients with type 2 diabetes treated …- Advantages and disadvantages of oral anticoagulants - LMW heparin dosing renal insufficiency (adults) - Anticoagulant dose adjustment in liver disease - Possible contraindications to anticoagulation - Standard dosing of DOACs - DOACs PK and drug interactions - Inhibitors and inducers of P-glycoprotein drug efflux - DOAC absorption … skyscanner vuelos In February 2020, the World Health Organization (WHO) designated the disease COVID-19, which stands for coronavirus disease 2019 [ 1 ]. The WHO declared an end to the COVID-19 global health emergency in May 2023, more than three years after its emergence. This topic will discuss the virology, epidemiology, and prevention of COVID-19.Measures to cut down on leveraged crypto trades could entice institutional buyers and make bitcoin more useful as a currency. In an effort to curb cryptocurrency speculation, finan... merck sharp and dohme UpToDateThe spectrum of activity and pharmacology of combination beta-lactamase inhibitors, carbapenems, and monobactams will be reviewed here. The mechanisms of action and resistance and major adverse reactions of the beta-lactam antibiotics, issues related to penicillins, and cephalosporins are discussed separately. pbi to bos This topic will focus on the treatment of hypernatremia induced by water loss, which is the most common cause. The treatment of hypernatremia in patients with impaired thirst, with or without arginine vasopressin disorders, and with primary sodium overload will also be reviewed. The causes and evaluation of patients with hypernatremia and the ... sugar to water ratio for hummingbirds UpToDate, the evidence-based clinical decision support resource from Wolters Kluwer, is trusted at the point of care by clinicians worldwide. dogs e INTRODUCTION. —. Acute rhinosinusitis (ARS) is defined as symptomatic inflammation of the nasal cavity and paranasal sinuses ( figure 1) lasting less than four weeks. The term "rhinosinusitis" is preferred to "sinusitis" since inflammation of the sinuses rarely occurs without concurrent inflammation of the nasal mucosa [ 1 ]. youtube videos music Contents. You have access to the entire UpToDate® library of specialties with your subscription. Click on one of the specialties below to see sections associated with each. You can also view Practice Changing UpDates, What’s New, Patient Education, Authors and Editors, Calculators, and Drug Information. Practice Changing UpDates.Shingles, also known as herpes zoster, is a painful rash caused by varicella-zoster virus (the same virus that causes chickenpox). After a person has had chickenpox, the virus continues to reside in the body, causing no symptoms. Later in life, it can become active again, causing the shingles rash. The term "shingles" comes from the Latin word ... ally bank auto Trusted for more than 30 years, UpToDate® is the clinical decision support resource that provides over 2 million medical professionals worldwide with the latest evidence-based information available across 25 specialties. With the ever-increasing complexity of diseases, medicine, and clinical practice in today's world, UpToDate is dedicated to ...Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or … national african american museum dc Justin Bufkin of One Smile Closer shares how he started a photography business on the side. He shares tips on anyone can make money with photography. Part-Time Money® Make extra mo...Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or … ath to myk Hydroxocobalamin (vitamin B12a supplement and cyanide antidote): Pediatric drug information. Hydroxychloroquine: Pediatric drug information. Hydroxyprogesterone caproate (United States: Withdrawn from market): Pediatric drug information. Hydroxyurea (hydroxycarbamide): Pediatric drug information.Multiple antibiotic regimens have been evaluated for Helicobacter pylori ( H. pylori) therapy [ 1-6 ]. However, few regimens have consistently achieved high eradication rates. There are also limited data on H. pylori antibiotic resistance rates to guide therapy. The treatment regimen that is selected must consider local antibiotic resistance ... ut my registration Sep 7, 2022 · Chronic diarrhea is defined as three or more loose stools daily for at least four weeks. There are many possible causes of chronic diarrhea. Treatment is aimed at treating the underlying cause of diarrhea (whenever possible), firming up loose stools, and dealing with any complications of diarrhea.